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Antibody Product Overview
| ELK.No | ES14450 |
| Product name | NRAM2 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 4891 |
| Human Swiss-Prot | P49281 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NRAM2 |
| Fields | >>Lysosome;>>Ferroptosis;>>Mineral absorption;>>Alzheimer disease;>>Parkinson disease |
| Gene name | SLC11A2 DCT1 DMT1 NRAMP2 OK/SW-cl.20 |
| Protein name | NRAM2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 18174 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P49282 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25715 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | O54902 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human NRAM2 AA range: 474-524 |
| Specificity | This antibody detects endogenous levels of NRAM2 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.156% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010], |
| Function | disease:Defects in SLC11A2 are a cause of hypochromic microcytic anemia [MIM:206100]. The disease is characterized by an abnormal hemoglobin content in the erythrocytes which are reduced in size. It may be hereditary or acquired. Mutations in SLC11A2 are associated with progressive liver iron overload and normal to moderately elevated serum ferritin levels.,function:Macrophage-specific membrane transport. Important in metal transport, in particular iron.,similarity:Belongs to the NRAMP family.,tissue specificity:Expressed at low levels in all tissues analyzed., |
| Subcellular location | [Isoform 2]: Cell membrane ; Multi-pass membrane protein . Early endosome .; Endosome membrane ; Multi-pass membrane protein . Mitochondrion outer membrane ; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein . Also found in extracellular vesicles different from exosomes. . |
| Expression | Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney. |
Additional Images
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Western blot analysis of lysates from A431 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14450-100
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