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Antibody Product Overview
| ELK.No | ES14480 |
| Product name | NLRC4 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 58484 |
| Human Swiss-Prot | Q9NPP4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NLRC4 |
| Fields | >>NOD-like receptor signaling pathway;>>Shigellosis;>>Salmonella infection;>>Legionellosis;>>Yersinia infection |
| Gene name | NLRC4 CARD12 CLAN CLAN1 IPAF UNQ6189/PRO20215 |
| Protein name | NLRC4 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 268973 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q3UP24 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | F1M649 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human NLRC4 AA range: 481-531 |
| Specificity | This antibody detects endogenous levels of NLRC4 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 113kD |
| Observed band (KD) | |
| Background | This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014], |
| Function | function:Plays a role in the promotion of apoptosis.,similarity:Contains 1 CARD domain.,similarity:Contains 1 NACHT domain.,similarity:Contains 14 LRR (leucine-rich) repeats.,subcellular location:Cytoplasmic filaments.,subunit:Self-associates and binds to ASC, pro-caspase-1, NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction.,tissue specificity:Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain., |
| Subcellular location | Cytoplasm . Cytoplasm, cytosol . Inflammasome . |
| Expression | Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain. |
Additional Images
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Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14480-100
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