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Antibody Product Overview
| ELK.No | ES14484 |
| Product name | NKD2 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 85409 |
| Human Swiss-Prot | Q969F2 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NKD2 |
| Fields | >>Wnt signaling pathway;>>Hippo signaling pathway |
| Gene name | NKD2 |
| Protein name | NKD2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 72293 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8VE28 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human NKD2 AA range: 311-361 |
| Specificity | This antibody detects endogenous levels of NKD2 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 50kD |
| Observed band (KD) | |
| Background | This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012], |
| Function | developmental stage:Expressed in fetal kidney and lung.,function:Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.,similarity:Belongs to the NKD family.,similarity:Contains 1 EF-hand domain.,subunit:Interacts with DVL1, DVL2, DVL3 and PPP2R3A (By similarity). Interacts with TGFA.,tissue specificity:Expressed in kidney, lung, pancreas and spleen., |
| Subcellular location | Cell membrane . Cytoplasm . Cytoplasmic vesicle . |
| Expression | Expressed in kidney, lung, pancreas and spleen. |
Additional Images
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Western blot analysis of lysates from SW480 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14484-100
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