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GABAA Rβ1 (phospho Ser434) rabbit pAb
AO-06-ES1452-50
Antibody Product Overview
| ELK.No | ES1452 |
| Product name | GABAA Rβ1 (phospho Ser434) rabbit pAb |
| Reactivity | Human;Mouse;Rat;Monkey |
| Applications | WB;IHC;IF;ELISA |
| Other name | GABRB1; Gamma-aminobutyric acid receptor subunit beta-1; GABA(A) receptor subunit beta-1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2560 |
| Human Swiss-Prot | P18505 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GABAA Rβ1 |
| Fields | >>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>Serotonergic synapse;>>GABAergic synapse;>>Morphine addiction;>>Nicotine addiction |
| Gene name | GABRB1 |
| Protein name | Gamma-aminobutyric acid receptor subunit beta-1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14400 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P50571 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25450 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P15431 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GABA-RB around the phosphorylation site of Ser434. AA range:401-450 |
| Specificity | Phospho-GABAA Rβ1 (S434) Polyclonal Antibody detects endogenous levels of GABAA Rβ1 protein only when phosphorylated at S434. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 55kD |
| Background | The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008], |
| Function | function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho., |
| Subcellular location | Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . |
| Expression | Brain,Epithelium, |
Additional Images
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Western Blot analysis of various cells using Phospho-GABAA Rβ1 (S434) Polyclonal Antibody
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Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using GABA-RB (Phospho-Ser434) Antibody
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Immunohistochemistry analysis of paraffin-embedded human brain, using GABA-RB (Phospho-Ser434) Antibody. The picture on the right is blocked with the phospho peptide.
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Western blot analysis of lysates from COS7 cells, using GABA-RB (Phospho-Ser434) Antibody. The lane on the right is blocked with the phospho peptide.
: AO-06-ES1452-50
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