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Antibody Product Overview
| ELK.No | ES14568 |
| Product name | NALP4 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 147945 |
| Human Swiss-Prot | Q96MN2 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NALP4 |
| Fields | >>Pathogenic Escherichia coli infection |
| Gene name | NLRP4 NALP4 PAN2 PYPAF4 RNH2 |
| Protein name | NALP4 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human NALP4 AA range: 307-357 |
| Specificity | This antibody detects endogenous levels of NALP4 at Human |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 109kD |
| Observed band (KD) | |
| Background | NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008], |
| Function | alternative products:Experimental confirmation may be lacking for some isoforms,function:May be involved in inflammation.,sequence caution:Translated as Gln.,similarity:Belongs to the NLRP family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 1 NACHT domain.,similarity:Contains 8 LRR (leucine-rich) repeats., |
| Subcellular location | cytosol,extracellular exosome, |
| Expression |
Additional Images
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Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human uterus. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES14568-50
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