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Antibody Product Overview
| ELK.No | ES14678 |
| Product name | MTU1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 55687 |
| Human Swiss-Prot | O75648 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MTU1 |
| Fields | |
| Gene name | TRMU MTU1 TRMT1 |
| Protein name | MTU1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 72026 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9DAT5 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | B1WC37 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human MTU1 AA range: 368-418 |
| Specificity | This antibody detects endogenous levels of MTU1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 46kD |
| Observed band (KD) | |
| Background | This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013], |
| Function | caution:Was originally (PubMed:16513084) thought to be a 5-methylaminomethyl-2-methyltransferase involved in tRNA modification.,function:Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.,miscellaneous:During the reaction, ATP is used to activate the C2 atom of U34 by adenylation. After this, the persulfide sulfur on the catalytic cysteine is transferred to the C2 atom of the wobble base (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards the activated C2 atom on U34. Subsequen |
| Subcellular location | Mitochondrion . |
| Expression | Ubiquitous. Abundantly expressed in tissues with high metabolic rates including heart, liver, kidney, and brain. |
Additional Images
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Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14678-100
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