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Antibody Product Overview
| ELK.No | ES14702 |
| Product name | MSH5 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB;IHC |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 4439 |
| Human Swiss-Prot | O43196 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MSH5 |
| Fields | |
| Gene name | MSH5 |
| Protein name | MSH5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 17687 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9QUM7 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 294252 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q6MG62 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human MSH5 AA range: 13-63 |
| Specificity | This antibody detects endogenous levels of MSH5 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 92kD |
| Observed band (KD) | |
| Background | This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011], |
| Function | function:Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis.,similarity:Belongs to the DNA mismatch repair mutS family.,subunit:Heterooligomer of MSH4 and MSH5. Interacts with HJURP.,tissue specificity:Ubiquitous, but highly expressed in testis, and thymus., |
| Subcellular location | synaptonemal complex,mismatch repair complex, |
| Expression | Widely expressed, with high levels in testis and ovary, including granulosa cells (PubMed:9740671, PubMed:28175301). Also expressed in fetal ovary and adrenal gland (PubMed:28175301). |
Additional Images
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Western blot analysis of lysates from 3T3 cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES14702-50
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