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Antibody Product Overview
| ELK.No | ES14707 |
| Product name | MS4A3 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 932 |
| Human Swiss-Prot | Q96HJ5 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MS4A3 |
| Fields | |
| Gene name | MS4A3 CD20L HTM4 |
| Protein name | MS4A3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 170813 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q920C4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human MS4A3 AA range: 101-151 |
| Specificity | This antibody detects endogenous levels of MS4A3 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 24kD |
| Observed band (KD) | |
| Background | This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008], |
| Function | caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.,function:Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).,similarity:Belongs to the MS4A family.,subcellular location:Located in the perinuclear area.,subunit:Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes.,tissue specificity:Expressed specifically in hematopoietic cells and tissues., |
| Subcellular location | Endomembrane system ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Located in the perinuclear area. |
| Expression | Expressed specifically in hematopoietic cells and tissues. |
Additional Images
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Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14707-100
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