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PLC β3 (phospho Ser1105) rabbit pAb
AO-06-ES1475-100
Antibody Product Overview
| ELK.No | ES1475 |
| Product name | PLC β3 (phospho Ser1105) rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | PLCB3; 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase beta-3; Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3; PLC-beta-3 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 5331 |
| Human Swiss-Prot | Q01970 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PLCβ3 |
| Fields | >>Inositol phosphate metabolism;>>Metabolic pathways;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>cGMP-PKG signaling pathway;>>Chemokine signaling pathway;>>Phosphatidylinositol signaling system;>>Sphingolipid signaling pathway;>>Phospholipase D signaling pathway;>>Adrenergic signaling in cardiomyocytes;>>Vascular smooth muscle contraction;>>Wnt signaling pathway;>>Apelin signaling pathway;>>Gap junction;>>Platelet activation;>>Neutrophil extracellular trap formation;>>NOD-like receptor signaling pathway;>>Circadian entrainment;>>Long-term potentiation;>>Retrograde endocannabinoid signaling;>>Glutamatergic synapse;>>Cholinergic synapse;>>Serotonergic synapse;>>Dopaminergic synapse;>>Long-term depression;>>Taste transduction;>>Inflammatory mediator regulation of TRP channels;>>Insulin secretion;>>GnRH signaling pathway;>>Estrogen signaling pathway;>>Melanogenesis;>>Thyroid hormone synthesis;>>Thyroid hormone signaling pathway;>>Oxytocin signaling pathway;>>Glucagon signaling p |
| Gene name | PLCB3 |
| Protein name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P51432 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q99JE6 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PLCB3 around the phosphorylation site of Ser1105. AA range:1071-1120 |
| Specificity | Phospho-PLC β3 (S1105) Polyclonal Antibody detects endogenous levels of PLC β3 protein only when phosphorylated at S1105. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 160kD |
| Background | This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010], |
| Function | catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,subunit:Interacts with SHANK2 (By similarity). Interacts with LPAR2., |
| Subcellular location | Cytoplasm . Membrane . Nucleus . And particulate fractions. . |
| Expression | Epithelium,Uterus, |
Additional Images
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Western Blot analysis of various cells using Phospho-PLC β3 (S1105) Polyclonal Antibody diluted at 1:1000
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Immunohistochemical analysis of paraffin-embedded Human breast cancer. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
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Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using PLCB3 (Phospho-Ser1105) Antibody
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Immunohistochemistry analysis of paraffin-embedded human brain, using PLCB3 (Phospho-Ser1105) Antibody. The picture on the right is blocked with the phospho peptide.
: AO-06-ES1475-100
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