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Antibody Product Overview
| ELK.No | ES15134 |
| Product name | LONM rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | Lon protease homolog, mitochondrial (EC 3.4.21.-) (LONHs) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9361 |
| Human Swiss-Prot | P36776 |
| Source | Rabbit |
| Isotype | IgG |
| Target | LONM |
| Fields | |
| Gene name | LONP1 PRSS15 |
| Protein name | LONM |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 74142 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8CGK3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 170916 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q924S5 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human LONM AA range: 398-448 |
| Specificity | This antibody detects endogenous levels of LONM at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.251% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 105kD |
| Background | This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013], |
| Function | function:Required for intramitochondrial proteolysis. Catalyzes the initial steps of protein degradation. Hydrolyzes ATP and degrades protein and peptide substrates in an ATP-dependent manner. Binds to single-stranded but not to double-stranded DNA.,similarity:Belongs to the peptidase S16 family.,similarity:Contains 1 Lon domain.,tissue specificity:Duodenum, heart, lung and liver, but not thymus., |
| Subcellular location | Mitochondrion matrix . |
| Expression | Duodenum, heart, lung and liver, but not thymus. |
Additional Images
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Western blot analysis of lysates from PC-12 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15134-50
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