Français
English
Antibody Product Overview
| ELK.No | ES15143 |
| Product name | LLR1 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 122769 |
| Human Swiss-Prot | Q96L50 |
| Source | Rabbit |
| Isotype | IgG |
| Target | LLR1 |
| Fields | |
| Gene name | LRR1 PPIL5 |
| Protein name | LLR1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human LLR1 AA range: 116-166 |
| Specificity | This antibody detects endogenous levels of LLR1 at Human |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 46kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011], |
| Function | function:May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 5 LRR (leucine-rich) repeats.,subunit:Interacts with the cytoplasmic domain of TNFRSF9. Component of the probable ECS(PPIL5) E3 ubiquitin-protein ligase complex which contains CUL2, RBX1, Elongin BC complex and PPIL5. Interacts with CUL2, RBX1, TCEB1 and TCEB2.,tissue specificity:Ubiquitous. Maximal expression was seen in the heart and skeletal muscle and minimal expression seen in the kidney., |
| Subcellular location | |
| Expression | Ubiquitous. Maximal expression was seen in the heart and skeletal muscle and minimal expression seen in the kidney. |
Additional Images
No image
Western blot analysis of lysates from HCT116 cells, primary antibody was diluted at 1:1000, 4°over night
No image
No image
No image
: AO-06-ES15143-50
: 10 Produits
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package