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Antibody Product Overview
| ELK.No | ES15170 |
| Product name | LEO1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB;ELISA;IHC |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 123169 |
| Human Swiss-Prot | Q8WVC0 |
| Source | Rabbit |
| Isotype | IgG |
| Target | LEO1 |
| Fields | |
| Gene name | LEO1 RDL |
| Protein name | LEO1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 235497 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q5XJE5 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 300837 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q641X2 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human LEO1 AA range: 159-209 |
| Specificity | This antibody detects endogenous levels of LEO1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 73kD |
| Observed band (KD) | |
| Background | LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008], |
| Function | function:The PAF1 complex is a multifunctional complex. The PAF1 complex interacts with POLR2A. May be involved in both initiation and elongation, histone methylation and RNA processing. Overexpression of LEO1 induces cell growth arrest and premature senescence of fibroblasts.,similarity:Belongs to the LEO1 family.,subunit:Component of the PAF1 complex, which consists of at least of CDC73, PAF1, LEO1 and CTR9. Interacts with CDC73.,tissue specificity:Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver., |
| Subcellular location | Nucleus . |
| Expression | Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver. |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES15170-100
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