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LDHA (phospho-Tyr10) rabbit pAb
AO-06-ES15173-50
Antibody Product Overview
| ELK.No | ES15173 |
| Product name | LDHA (phospho-Tyr10) rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA;IHC |
| Other name | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 3939 |
| Human Swiss-Prot | P00338 |
| Source | Rabbit |
| Isotype | IgG |
| Target | LDHA |
| Fields | >>Glycolysis / Gluconeogenesis;>>Cysteine and methionine metabolism;>>Pyruvate metabolism;>>Propanoate metabolism;>>Metabolic pathways;>>HIF-1 signaling pathway;>>Glucagon signaling pathway;>>Central carbon metabolism in cancer |
| Gene name | LDHA PIG19 |
| Protein name | LDHA (Tyr10) |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 16828 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P06151 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 24533 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P04642 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized phosho peptide around human LDHA (Tyr10) |
| Specificity | This antibody detects endogenous levels of Human Mouse Rat LDHA (phospho-Tyr10) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 36kD |
| Background | The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008], |
| Function | catalytic activity:(S)-lactate + NAD(+) = pyruvate + NADH.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in LDHA are a cause of exertional myoglobinuria.,online information:Lactate dehydrogenase entry,pathway:Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.,similarity:Belongs to the LDH/MDH superfamily.,similarity:Belongs to the LDH/MDH superfamily. LDH family.,subunit:Homotetramer., |
| Subcellular location | Cytoplasm. |
| Expression | Predominantly expressed in anaerobic tissues such as skeletal muscle and liver. |
Additional Images
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Western blot analysis of lysates from SH-SY5Y cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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