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Antibody Product Overview
| ELK.No | ES15308 |
| Product name | KIF1B rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 23095 |
| Human Swiss-Prot | O60333 |
| Source | Rabbit |
| Isotype | IgG |
| Target | KIF1B |
| Fields | |
| Gene name | KIF1B KIAA0591 KIAA1448 |
| Protein name | KIF1B |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 16561 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q60575 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 117548 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | O88658 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human KIF1B AA range: 1331-1381 |
| Specificity | This antibody detects endogenous levels of KIF1B at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 200kD |
| Observed band (KD) | |
| Background | This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008], |
| Function | disease:Defects in KIF1B are the cause of Charcot-Marie-Tooth disease type 2A1 (CMT2A1) [MIM:118210]. CMT2A1 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.,function:Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility.,similarity:Belongs to the kinesin-like protein family.,similarity:Belongs to the kinesin-like protein family. U |
| Subcellular location | Cytoplasm, cytoskeleton. Mitochondrion . Cell projection, axon .; [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . |
| Expression | Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas. |
Additional Images
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Western blot analysis of lysates from THP-1 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15308-100
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