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Antibody Product Overview
| ELK.No | ES15334 |
| Product name | KERA rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Keratocan (KTN) (Keratan sulfate proteoglycan keratocan) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 11081 |
| Human Swiss-Prot | O60938 |
| Source | Rabbit |
| Isotype | IgG |
| Target | KERA |
| Fields | |
| Gene name | KERA SLRR2B |
| Protein name | KERA |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 16545 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O35367 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human KERA AA range: 26-76 |
| Specificity | This antibody detects endogenous levels of KERA at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.19% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 38kD |
| Background | The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010], |
| Function | disease:Defects in KERA are the cause of the autosomal recessive cornea plana 2 (CNA2) [MIM:217300]. In CNA2, the forward convex curvature is flattened, leading to a decrease in refraction, reduced visual activity, extreme hyperopia (usually plus 10 d or more), hazy corneal limbus, opacities in the corneal parenchyma, and marked arcus senilis (often detected at an early age). CNA2 is a rare disorder with a worldwide distribution, but a high prevalence in the Finnish population.,disease:Increased expression in the stroma of keratoconus corneas. Keratoconus is a noninflammatory disease characterized by thinning and scarring of the central portion of the cornea.,function:May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.,PTM:Binds keratan sulfate chains.,similarity:Belongs to the small leucine-rich proteoglycan (SLRP) family. Cla |
| Subcellular location | Secreted, extracellular space, extracellular matrix . |
| Expression | Cornea (at protein level) (PubMed:10802664, PubMed:11683372). Increased expression in the stroma of keratoconus corneas (PubMed:11683372). Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen (PubMed:10802664). |
Additional Images
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Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15334-50
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