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Annexin I (phospho Tyr21) rabbit pAb
AO-06-ES1534-50
Antibody Product Overview
| ELK.No | ES1534 |
| Product name | Annexin I (phospho Tyr21) rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | ANXA1; ANX1; LPC1; Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 301 |
| Human Swiss-Prot | P04083 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Annexin I |
| Fields | |
| Gene name | ANXA1 |
| Protein name | Annexin A1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P10107 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Annexin I (phospho Tyr21) |
| Specificity | Phospho-Annexin I (Y21) Polyclonal Antibody detects endogenous levels of Annexin I protein only when phosphorylated at Y21. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 39kD |
| Observed band (KD) | |
| Background | This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014], |
| Function | domain:A pair of annexin repeats may form one binding site for calcium and phospholipid.,function:Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.,PTM:Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity.,similarity:Belongs to the annexin family.,similarity:Contains 1 annexin repeat.,similarity:Contains 2 annexin repeats.,similarity:Contains 4 annexin repeats.,subcellular location:Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages.,subunit:Homodimer in placenta (20%); linked by transglutamylat |
| Subcellular location | Nucleus . Cytoplasm . Cell projection, cilium . Cell membrane . Membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Basolateral cell membrane . Apical cell membrane . Lateral cell membrane . Secreted . Secreted, extracellular space . Cell membrane ; Peripheral membrane protein ; Extracellular side . Secreted, extracellular exosome . Cytoplasmic vesicle, secretory vesicle lumen . Cell projection, phagocytic cup . Early endosome . Cytoplasmic vesicle membrane ; Peripheral membrane protein . Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Alternatively, the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in t |
| Expression | Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver. |
Additional Images
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Western Blot analysis of extracts from NIH-3T3 cells, using Phospho-Annexin I (Y21) Polyclonal Antibody.
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: AO-06-ES1534-50
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