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Antibody Product Overview
| ELK.No | ES15409 |
| Product name | ITM2C rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB;IHC |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 81618 |
| Human Swiss-Prot | Q9NQX7 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ITM2C |
| Fields | |
| Gene name | ITM2C BRI3 hucep-14 NPD018 PSEC0047 |
| Protein name | ITM2C |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 64294 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q91VK4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 301575 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q5PQL7 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human ITM2C AA range: 1-51 |
| Specificity | This antibody detects endogenous levels of ITM2C at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 29kD |
| Observed band (KD) | |
| Background | |
| Function | PTM:Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C.,similarity:Belongs to the ITM2 family.,similarity:Contains 1 BRICHOS domain.,subunit:Interacts with BACE1.,tissue specificity:High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs., |
| Subcellular location | Lysosome membrane ; Single-pass type II membrane protein . Cell membrane ; Single-pass type II membrane protein . |
| Expression | High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs. |
Additional Images
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Western blot analysis of lysates from MDA-MB cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES15409-100
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