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IRF-7 (phospho-Ser477) rabbit pAb
AO-06-ES15428-100
Antibody Product Overview
| ELK.No | ES15428 |
| Product name | IRF-7 (phospho-Ser477) rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC |
| Other name | Interferon regulatory factor 7 (IRF-7) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 3665 |
| Human Swiss-Prot | Q92985 |
| Source | Rabbit |
| Isotype | IgG |
| Target | IRF-7 |
| Fields | >>Toll-like receptor signaling pathway;>>NOD-like receptor signaling pathway;>>RIG-I-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway;>>Hepatitis C;>>Hepatitis B;>>Measles;>>Influenza A;>>Kaposi sarcoma-associated herpesvirus infection;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Viral carcinogenesis;>>Lipid and atherosclerosis |
| Gene name | IRF7 |
| Protein name | IRF-7 (Ser477) |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 54123 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P70434 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized phosho peptide around human IRF-7 (Ser477) |
| Specificity | This antibody detects endogenous levels of Human IRF-7 (phospho-Ser477) ,Mouse IRF-7 (phospho-Ser431), Rat IRF-7 (phospho-Ser429) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 55kD |
| Background | IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008], |
| Function | function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity. Activated by phosphorylation in response to infection. Activation leads to nuclear retention, DNA binding, and derepression of transactivation ability.,induction:By type I interferons.,PTM:In response to a viral infection, phosphorylated on the C-terminal serine cluster. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subcellular location:The phosphorylated and active form accumulates selectively in the nucleus.,subunit:Homodimer; phosphorylation-induced. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1; t |
| Subcellular location | Nucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus. |
| Expression | Expressed predominantly in spleen, thymus and peripheral blood leukocytes. |
Additional Images
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Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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Western Blot analysis of Hela treated or untreated by LPS lysis, using primary antibody at 1:1000 dilution. Secondary antibody(catalog#:RS23920) was diluted at 1:10000
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