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Antibody Product Overview
| ELK.No | ES15430 |
| Product name | IREB2 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 3658 |
| Human Swiss-Prot | P48200 |
| Source | Rabbit |
| Isotype | IgG |
| Target | IREB2 |
| Fields | |
| Gene name | IREB2 |
| Protein name | IREB2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 64602 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q811J3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 64831 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q62751 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human IREB2 AA range: 702-752 |
| Specificity | This antibody detects endogenous levels of IREB2 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.265% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 105kD |
| Background | |
| Function | cofactor:Binds 1 4Fe-4S cluster per subunit.,function:Binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.,similarity:Belongs to the aconitase/IPM isomerase family., |
| Subcellular location | Cytoplasm. |
| Expression | Brain, |
Additional Images
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Western blot analysis of lysates from HCT116 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15430-50
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