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Antibody Product Overview
| ELK.No | ES15449 |
| Product name | INT4 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Integrator complex subunit 4 (Int4) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 92105 |
| Human Swiss-Prot | Q96HW7 |
| Source | Rabbit |
| Isotype | IgG |
| Target | INT4 |
| Fields | |
| Gene name | INTS4 MSTP093 |
| Protein name | INT4 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 101861 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8CIM8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human INT4 AA range: 10-60 |
| Specificity | This antibody detects endogenous levels of INT4 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.262% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 105kD |
| Background | INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008], |
| Function | function:Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.,similarity:Belongs to the Integrator subunit 4 family.,similarity:Contains 8 HEAT repeats.,subunit:Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12., |
| Subcellular location | Nucleus . |
| Expression | Aorta,Brain,Muscle,Ovary,Uterus, |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15449-100
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