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Antibody Product Overview
| ELK.No | ES15471 |
| Product name | IMDH1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 3614 |
| Human Swiss-Prot | P20839 |
| Source | Rabbit |
| Isotype | IgG |
| Target | IMDH1 |
| Fields | >>Purine metabolism;>>Drug metabolism - other enzymes;>>Metabolic pathways;>>Nucleotide metabolism |
| Gene name | IMPDH1 IMPD1 |
| Protein name | IMDH1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 23917 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P50096 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | D3ZLZ7 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human IMDH1 AA range: 304-354 |
| Specificity | This antibody detects endogenous levels of IMDH1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 57kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008], |
| Function | catalytic activity:Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH.,cofactor:Potassium.,disease:Defects in IMPDH1 are the cause of retinitis pigmentosa type 10 (RP10) [MIM:180105]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP10 inheritance is autosomal dominant.,function:Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.,online information:Retina International's Scientific Newsletter,pathway:Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.,similar |
| Subcellular location | Cytoplasm . Nucleus . |
| Expression | IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor. |
Additional Images
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Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15471-100
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