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Antibody Product Overview
| ELK.No | ES15597 |
| Product name | HSH2D rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 84941 |
| Human Swiss-Prot | Q96JZ2 |
| Source | Rabbit |
| Isotype | IgG |
| Target | HSH2D |
| Fields | |
| Gene name | HSH2D ALX |
| Protein name | HSH2D |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 209488 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q6VYH9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human HSH2D AA range: 288-338 |
| Specificity | This antibody detects endogenous levels of HSH2D at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.18% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 38kD |
| Background | T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008], |
| Function | caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.,PTM:May be phosphorylated by FES and ACK1.,similarity:Contains 1 SH2 domain.,subunit:Interacts with FES and TNK2.,tissue specificity:Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta., |
| Subcellular location | Cytoplasm. Nucleus. |
| Expression | Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta. |
Additional Images
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Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15597-50
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