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Antibody Product Overview
| ELK.No | ES1561 |
| Product name | ABCA6 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | ABCA6; ATP-binding cassette sub-family A member 6 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 23460 |
| Human Swiss-Prot | Q8N139 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ABCA6 |
| Fields | >>ABC transporters |
| Gene name | ABCA6 |
| Protein name | ATP-binding cassette sub-family A member 6 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q8K441 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from ABCA6 . at AA range: 1180-1260 |
| Specificity | ABCA6 Polyclonal Antibody detects endogenous levels of ABCA6 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 185kD |
| Background | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24 and may play a role in macrophage lipid homeostasis. [provided by RefSeq, Jul 2008], |
| Function | developmental stage:Expressed in fetal kidney, lung and liver.,function:Probable transporter which may play a role in macrophage lipid homeostasis.,induction:Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages.,similarity:Belongs to the ABC transporter family. ABCA subfamily.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Widely expressed with higher expression in liver., |
| Subcellular location | Golgi apparatus membrane ; Multi-pass membrane protein . |
| Expression | Widely expressed with higher expression in liver. |
Additional Images
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Western Blot analysis of various cells using ABCA6 Polyclonal Antibody
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: AO-06-ES1561-50
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