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Antibody Product Overview
| ELK.No | ES15779 |
| Product name | HERC3 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8916 |
| Human Swiss-Prot | Q15034 |
| Source | Rabbit |
| Isotype | IgG |
| Target | HERC3 |
| Fields | >>Ubiquitin mediated proteolysis |
| Gene name | HERC3 KIAA0032 |
| Protein name | HERC3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human HERC3 AA range: 985-1035 |
| Specificity | This antibody detects endogenous levels of HERC3 at Human |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 116kD |
| Observed band (KD) | |
| Background | This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012], |
| Function | function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,PTM:Ubiquitinated; which promotes degradation by the proteasome.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 7 RCC1 repeats.,subcellular location:Also found in vesicular-like structures., |
| Subcellular location | Cytoplasm. Cytoplasmic vesicle. Also found in vesicular-like structures. |
| Expression |
Additional Images
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Western blot analysis of lysates from 3T3 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15779-50
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