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Antibody Product Overview
| ELK.No | ES15906 |
| Product name | GRIK3 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2899 |
| Human Swiss-Prot | Q13003 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GRIK3 |
| Fields | >>Neuroactive ligand-receptor interaction;>>Glutamatergic synapse |
| Gene name | GRIK3 GLUR7 |
| Protein name | GRIK3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14807 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | B1AS29 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 298521 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P42264 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human GRIK3 AA range: 209-259 |
| Specificity | This antibody detects endogenous levels of GRIK3 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 101kD |
| Observed band (KD) | |
| Background | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008], |
| Function | function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.,RNA editing:Partially edited.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Homomeric. Can also coassemble with either GRIK4 or GRIK5 to form heteromeric receptors. Interacts with PRKCABP., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
| Expression |
Additional Images
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Western blot analysis of lysates from 293T cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15906-100
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