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Antibody Product Overview
| ELK.No | ES1597 |
| Product name | ACTR-IB rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | ACVR1B; ACVRLK4; ALK4; Activin receptor type-1B; Activin receptor type IB; ACTR-IB; Activin receptor-like kinase 4; ALK-4; Serine/threonine-protein kinase receptor R2; SKR2 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 91 |
| Human Swiss-Prot | P36896 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ACTR-IB |
| Fields | >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Signaling pathways regulating pluripotency of stem cells |
| Gene name | ACVR1B |
| Protein name | Activin receptor type-1B |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 11479 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q61271 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 29381 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P80202 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ACV1B. AA range:73-122 |
| Specificity | ACTR-IB Polyclonal Antibody detects endogenous levels of ACTR-IB protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 56kD |
| Background | This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010], |
| Function | catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TTRAP.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 GS domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3. Interacts with TTRAP.,tissue specificity:Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver., |
| Subcellular location | Cell membrane ; Single-pass type I membrane protein . |
| Expression | Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. |
Additional Images
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Western Blot analysis of various cells using ACTR-IB Polyclonal Antibody diluted at 1:1000
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Immunofluorescence analysis of HeLa cells, using ACV1B Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from 293 and mouse liver cells, using ACV1B Antibody. The lane on the right is blocked with the synthesized peptide.
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Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
: AO-06-ES1597-100
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