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Antibody Product Overview
| ELK.No | ES16149 |
| Product name | GMCLL rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | |
| Human Swiss-Prot | Q8NEA9 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GMCLL |
| Fields | |
| Gene name | GMCL1P1 GCL GMCL1L |
| Protein name | GMCLL |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 100040533 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q99N64 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human GMCLL AA range: 20-70 |
| Specificity | This antibody detects endogenous levels of GMCLL at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 58kD |
| Observed band (KD) | |
| Background | This locus shares a high degree of identity with the multi-exon germ cell-less gene on chromosome 2. Despite its single-exon nature, this chromosome 5 locus contains an open reading frame that could putatively encode a full-length germ cell-less related protein. [provided by RefSeq, Jul 2008], |
| Function | function:Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,function:Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 BTB (POZ) domain.,subunit:Interacts with TMPO-beta, TSG101 and TFDP2 (By similarity). Interacts with EMD.,subunit:Interacts with TMPO-Beta, TSG101 and TFDP2. Interacts with EMD (By similarity). Interacts with CUL3., |
| Subcellular location | Nucleus matrix . |
| Expression | Expressed predominantly in testis. |
Additional Images
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Western blot analysis of lysates from DU145 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16149-100
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