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Antibody Product Overview
| ELK.No | ES16229 |
| Product name | GATM rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2628 |
| Human Swiss-Prot | P50440 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GATM |
| Fields | >>Glycine, serine and threonine metabolism;>>Arginine and proline metabolism;>>Metabolic pathways |
| Gene name | GATM AGAT |
| Protein name | GATM |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 67092 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9D964 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 81660 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P50442 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human GATM AA range: 223-273 |
| Specificity | This antibody detects endogenous levels of GATM at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 47kD |
| Observed band (KD) | |
| Background | This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:L-arginine + glycine = L-ornithine + guanidinoacetate.,disease:Defects in GATM are the cause of L-arginine:glycine amidinotransferase deficiency (AGAT deficiency) [MIM:602360]. AGAT deficiency is a defect in creatine metabolism leading to mental retardation.,domain:One chain folds into a compact single domain composed of repeating units, five beta-beta-alpha-beta modules, which surround the central active site.,pathway:Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 1/2.,similarity:Belongs to the amidinotransferase family.,subcellular location:The mitochondrial form is found in the intermembrane space probably attached to the outer side of the inner membrane.,subunit:Homodimer. There is an equilibrium between the monomeric and dimeric forms, shifted towards the side of the monomer.,tissue specificity:Kidney., |
| Subcellular location | [Isoform 1]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Probably attached to the outer side of the inner membrane.; [Isoform 2]: Cytoplasm. |
| Expression | Expressed in brain, heart, kidney, liver, lung, salivary gland and skeletal muscle tissue, with the highest expression in kidney. Biallelically expressed in placenta and fetal tissues. |
Additional Images
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Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16229-100
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