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Antibody Product Overview
| ELK.No | ES16305 |
| Product name | FXL12 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 54850 |
| Human Swiss-Prot | Q9NXK8 |
| Source | Rabbit |
| Isotype | IgG |
| Target | FXL12 |
| Fields | |
| Gene name | FBXL12 FBL12 |
| Protein name | FXL12 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 30843 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9EPX5 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human FXL12 AA range: 8-58 |
| Specificity | This antibody detects endogenous levels of FXL12 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 36kD |
| Observed band (KD) | |
| Background | Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008], |
| Function | function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,similarity:Contains 5 LRR (leucine-rich) repeats.,subunit:Interacts with SKP1A and CUL1., |
| Subcellular location | ubiquitin ligase complex,cytoplasm,integral component of membrane, |
| Expression |
Additional Images
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Western blot analysis of lysates from Jarkat cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16305-50
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