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FRS2-α (phospho-Tyr196) rabbit pAb
AO-06-ES16317-50
Antibody Product Overview
| ELK.No | ES16317 |
| Product name | FRS2-α (phospho-Tyr196) rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB |
| Other name | Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 10818 |
| Human Swiss-Prot | Q8WU20 |
| Source | Rabbit |
| Isotype | IgG |
| Target | FRS2 |
| Fields | >>Thermogenesis;>>Neurotrophin signaling pathway;>>Proteoglycans in cancer |
| Gene name | FRS2 |
| Protein name | FRS2-α (Tyr196) |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 327826 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8C180 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized phosho peptide around human FRS2-α (Tyr196) |
| Specificity | This antibody detects endogenous levels of Human Mouse FRS2-α (phospho-Tyr196) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:1000-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 65kD |
| Background | |
| Function | function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and t |
| Subcellular location | Endomembrane system. Cytoplasmic, membrane-bound. |
| Expression | Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. |
Additional Images
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Western Blot analysis of Hela treated or untreated by LPS lysis, using primary antibody at 1:1000 dilution. Secondary antibody(catalog#:RS23920) was diluted at 1:10000
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: AO-06-ES16317-50
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