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Antibody Product Overview
| ELK.No | ES16497 |
| Product name | FBXW5 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 54461 |
| Human Swiss-Prot | Q969U6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | FBXW5 |
| Fields | |
| Gene name | FBXW5 FBW5 PP3971 |
| Protein name | FBXW5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 30839 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9QXW2 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 362081 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q4KLI9 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human FBXW5 AA range: 319-369 |
| Specificity | This antibody detects endogenous levels of FBXW5 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.132% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008], |
| Function | function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,similarity:Contains 3 WD repeats.,subunit:Interacts with SKP1A and CUL1., |
| Subcellular location | Cytoplasm . |
| Expression | Brain,Cervix,Colon,Ovary,Placenta,Skin,Testis, |
Additional Images
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Western blot analysis of lysates from DU145 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16497-50
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