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Antibody Product Overview
| ELK.No | ES16527 |
| Product name | FAN rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8439 |
| Human Swiss-Prot | Q92636 |
| Source | Rabbit |
| Isotype | IgG |
| Target | FAN |
| Fields | >>Sphingolipid signaling pathway |
| Gene name | NSMAF FAN |
| Protein name | FAN |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 18201 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O35242 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human FAN AA range: 147-197 |
| Specificity | This antibody detects endogenous levels of FAN at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 101kD |
| Observed band (KD) | |
| Background | This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009], |
| Function | function:Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.,similarity:Contains 1 BEACH domain.,similarity:Contains 1 GRAM domain.,similarity:Contains 6 WD repeats.,tissue specificity:Ubiquitous., |
| Subcellular location | cytoplasm,cytosol,endomembrane system,extrinsic component of membrane, |
| Expression | Ubiquitous. |
Additional Images
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Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16527-50
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