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Antibody Product Overview
| ELK.No | ES16753 |
| Product name | EMD rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2010 |
| Human Swiss-Prot | P50402 |
| Source | Rabbit |
| Isotype | IgG |
| Target | EMD |
| Fields | >>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy |
| Gene name | EMD EDMD STA |
| Protein name | EMD |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 13726 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O08579 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25437 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q63190 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human EMD AA range: 151-201 |
| Specificity | This antibody detects endogenous levels of EMD at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 28kD |
| Observed band (KD) | |
| Background | Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008], |
| Function | disease:Defects in EMD are a cause of X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) [MIM:310300]. X-EDMD is an X-linked disorder characterized by early contractures, muscle wasting and weakness and cardiomyopathy.,miscellaneous:Binding to BCLAF1 is specifically and selectively disrupted by the disease-associated Phe-54 missense mutation.,online information:"EMD mutation database",PTM:Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.,similarity:Contains 1 LEM domain.,subcellular location:Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites.,subunit:Interacts with lamins A and C, BANF1, GMCL, BCLAF1 and YTHDC1/YT521. Interacts with TMEM43; the interaction retains emerin in the nuclear inner membrane.,tissue specificity:Skeletal muscle, heart, colon, testis, ovary and pancreas. |
| Subcellular location | Nucleus inner membrane ; Single-pass membrane protein; Nucleoplasmic side . Nucleus outer membrane. Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus. |
| Expression | Skeletal muscle, heart, colon, testis, ovary and pancreas. |
Additional Images
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Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16753-100
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