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Antibody Product Overview
| ELK.No | ES16881 |
| Product name | DUOX1 rabbit pAb |
| Reactivity | Human;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 53905 |
| Human Swiss-Prot | Q9NRD9 |
| Source | Rabbit |
| Isotype | IgG |
| Target | DUOX1 |
| Fields | >>Thyroid hormone synthesis |
| Gene name | DUOX1 DUOX LNOX1 THOX1 |
| Protein name | DUOX1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | 266807 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q8CIY2 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human DUOX1 AA range: 1398-1448 |
| Specificity | This antibody detects endogenous levels of DUOX1 at Human/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 171kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012], |
| Function | catalytic activity:NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).,developmental stage:Widely expressed in fetal tissues.,enzyme regulation:The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide.,function:Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.,induction:By forskolin (at protein level). By thyrotropin and the Th2-specific cytokines IL-4 and IL-13.,pathway:Hormone biosynthesis; thyroid hormone biosynthesis.,PTM:N-glycosylated.,sequence caution:Translated as Arg.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 ferric oxidoreductase domain.,similarity:Co |
| Subcellular location | Apical cell membrane ; Multi-pass membrane protein . Localizes to the apical membrane of epithelial cells. |
| Expression | Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart. |
Additional Images
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Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16881-50
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