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Antibody Product Overview
| ELK.No | ES16896 |
| Product name | DREB rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 1627 |
| Human Swiss-Prot | Q16643 |
| Source | Rabbit |
| Isotype | IgG |
| Target | DREB |
| Fields | |
| Gene name | DBN1 D0S117E |
| Protein name | DREB |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 56320 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9QXS6 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 81653 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q07266 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human DREB AA range: 484-534 |
| Specificity | This antibody detects endogenous levels of DREB at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 71kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008], |
| Function | function:Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively.,similarity:Contains 1 ADF-H domain.,subunit:Binds F-actin.,tissue specificity:Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas., |
| Subcellular location | Cytoplasm . Cell projection, dendrite . Cytoplasm, cell cortex . Cell junction . Cell projection, growth cone . In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm (PubMed:20215400). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400). Colocalized with RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity). . |
| Expression | Expressed in the brain, with expression in the molecular layer of the dentate gyrus, stratum pyramidale, and stratum radiatum of the hippocampus (at protein level) (PubMed:8838578). Also expressed in the terminal varicosities distributed along dendritic trees of pyramidal cells in CA4 and CA3 of the hippocampus (at protein level) (PubMed:8838578). Expressed in pyramidal cells in CA2, CA1 and the subiculum of the hippocampus (at protein level) (PubMed:8838578). Expressed in peripheral blood lymphocytes, including T-cells (at protein level) (PubMed:20215400). Expressed in the brain (PubMed:8216329, Ref.2). Expressed in the heart, placenta, lung, skeletal muscle, kidney, pancreas, skin fibroblasts, gingival fibroblasts and bone-derived cells (Ref.2). |
Additional Images
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Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16896-100
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