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Antibody Product Overview
| ELK.No | ES1690 |
| Product name | AQP5 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | AQP5; Aquaporin-5; AQP-5 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 362 |
| Human Swiss-Prot | P55064 |
| Source | Rabbit |
| Isotype | IgG |
| Target | AQP5 |
| Fields | >>Salivary secretion |
| Gene name | AQP5 |
| Protein name | Aquaporin-5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9WTY4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AQP5. AA range:194-243 |
| Specificity | AQP5 Polyclonal Antibody detects endogenous levels of AQP5 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 35kD |
| Background | Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008], |
| Function | domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).,function:Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.,similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family., |
| Subcellular location | Apical cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Hypotonicity increases location at the cell membrane. Phosphorylation decreases location at the cell membrane. . |
| Expression | Detected in skin eccrine sweat glands, at the apical cell membrane and at intercellular canaliculi (at protein level). |
Additional Images
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Western Blot analysis of various cells using AQP5 Polyclonal Antibody
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Immunohistochemistry analysis of AQP5 antibody in paraffin-embedded human lung carcinoma tissue.
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Western blot analysis of lysate from HUVECcells, using AQP5 antibody.
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: AO-06-ES1690-50
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