Français
English
Antibody Product Overview
| ELK.No | ES16918 |
| Product name | DOC2A rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8448 |
| Human Swiss-Prot | Q14183 |
| Source | Rabbit |
| Isotype | IgG |
| Target | DOC2A |
| Fields | |
| Gene name | DOC2A |
| Protein name | DOC2A |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 13446 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q7TNF0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 65031 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P70611 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human DOC2A AA range: 22-72 |
| Specificity | This antibody detects endogenous levels of DOC2A at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 44kD |
| Observed band (KD) | |
| Background | There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013], |
| Function | domain:C2 domain 1 is involved in binding calcium and phospholipids.,function:May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in dynein-dependent intracellular vesicle transport. In vitro, binds calcium and phospholipids.,similarity:Contains 2 C2 domains.,subcellular location:Colocalizes to synaptic vesicles.,subunit:Interacts through its N-terminus with UNC13A. Interacts with cytoplasmic dynein light chain TCTEL1/TCTEX1.,tissue specificity:Predominantly expressed in brain. Also expressed in testis., |
| Subcellular location | Lysosome . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein . Cell junction, synapse, synaptosome. |
| Expression | Predominantly expressed in brain. Also expressed in testis. |
Additional Images
No image
Western blot analysis of lysates from A431 cells, primary antibody was diluted at 1:1000, 4°over night
No image
No image
No image
: AO-06-ES16918-50
: 10 Produits
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package