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Antibody Product Overview
| ELK.No | ES16949 |
| Product name | DHSO rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB;IP |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6652 |
| Human Swiss-Prot | Q00796 |
| Source | Rabbit |
| Isotype | IgG |
| Target | DHSO |
| Fields | >>Pentose and glucuronate interconversions;>>Fructose and mannose metabolism;>>Metabolic pathways |
| Gene name | SORD |
| Protein name | DHSO |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20322 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q64442 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 24788 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P27867 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human DHSO |
| Specificity | This antibody detects endogenous levels of DHSO at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 IP 1:200 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 39kD |
| Observed band (KD) | |
| Background | Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010], |
| Function | catalytic activity:L-iditol + NAD(+) = L-sorbose + NADH.,cofactor:Binds 1 zinc ion per subunit.,similarity:Belongs to the zinc-containing alcohol dehydrogenase family.,subunit:Homotetramer., |
| Subcellular location | Mitochondrion membrane ; Peripheral membrane protein . Cell projection, cilium, flagellum . Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. . |
| Expression | Expressed in liver (PubMed:3365415). Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level). |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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1) Input: Hela Lysate 2) IP product: IP dilute 1: 200 Western blot analysis: primary antibody : 1:2000 Secondary antibody: Goat anti-Mouse IgG(RS0002), 1: 5000
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: AO-06-ES16949-50
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