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Antibody Product Overview
| ELK.No | ES16970 |
| Product name | DEN1B rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 163486 |
| Human Swiss-Prot | Q6P3S1 |
| Source | Rabbit |
| Isotype | IgG |
| Target | DEN1B |
| Fields | |
| Gene name | DENND1B C1orf218 FAM31B |
| Protein name | DEN1B |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 329260 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q3U1T9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human DEN1B AA range: 325-375 |
| Specificity | This antibody detects endogenous levels of DEN1B at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 47kD |
| Observed band (KD) | |
| Background | Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010], |
| Function | PTM:Isoform 5 is phosphorylated on Tyr-475 and Tyr-484.,similarity:Contains 1 dDENN domain.,similarity:Contains 1 DENN domain.,similarity:Contains 1 uDENN domain., |
| Subcellular location | Cytoplasm, cytosol . Cytoplasmic vesicle, clathrin-coated vesicle . |
| Expression | Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T-cells as compared with naive T-cells. |
Additional Images
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Western blot analysis of lysates from 293T cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16970-50
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