Français
English
Antibody Product Overview
| ELK.No | ES16973 |
| Product name | DEAF1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) (Zinc finger MYND domain-containing protein 5) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 10522 |
| Human Swiss-Prot | O75398 |
| Source | Rabbit |
| Isotype | IgG |
| Target | DEAF1 |
| Fields | |
| Gene name | DEAF1 SPN ZMYND5 |
| Protein name | DEAF1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 54006 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9Z1T5 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 83632 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | O88450 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human DEAF1 AA range: 515-565 |
| Specificity | This antibody detects endogenous levels of DEAF1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.125% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014], |
| Function | alternative products:Experimental confirmation may be lacking for some isoforms,caution:This protein was first known as suppressin (characterized in bovine neuroendocrine and immune cells). However, according to PubMed:9773984, it is uncertain whether it corresponds really to the suppressin also described in Ref.3. DEAF1 has been described as a nuclear dimeric protein and suppressin as a secreted monomeric protein.,disease:Defects in DEAF1 could confer a growth advantage to the mutated cell that may have implications for the development and progression of neoplasia, e.g. in the case of colorectal adenocarcinomas (CRC).,function:Transcription factor that binds to sequence with multiple copies of TTC[CG]G present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) AGGGTTCACCGAAAGTTCA. Activates t |
| Subcellular location | [Isoform 1]: Nucleus. Cytoplasm. Cytoplasmic in non-mucinous colorectal carcinoma. When expressed alone, localized almost exclusively in the nucleus but, when expressed with isoform 4, nuclear expression decreases to 32% and cytoplasmic expression increases by 270%.; [Isoform 2]: Secreted. Secreted in some cell types.; [Isoform 3]: Secreted. Secreted in some cell types.; [Isoform 4]: Cytoplasm. Nucleus. When expressed alone, localizes mainly in the cytoplasm but, when expressed with isoform 1, nuclear localization is enhanced. |
| Expression | Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells. Expression in pancreatic lymph nodes of patients with type 1 diabetes is 20 times higher than in healthy controls. Highly expressed in fetal and adult brain. |
Additional Images
No image
Western blot analysis of lysates from HCT116 cells, primary antibody was diluted at 1:1000, 4°over night
No image
No image
No image
: AO-06-ES16973-100
: 10 Produits
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package