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Antibody Product Overview
| ELK.No | ES16989 |
| Product name | DCTN3 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 11258 |
| Human Swiss-Prot | O75935 |
| Source | Rabbit |
| Isotype | IgG |
| Target | DCTN3 |
| Fields | >>Amyotrophic lateral sclerosis;>>Huntington disease;>>Pathways of neurodegeneration - multiple diseases;>>Salmonella infection |
| Gene name | DCTN3 DCTN22 |
| Protein name | DCTN3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 53598 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9Z0Y1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human DCTN3 AA range: 117-167 |
| Specificity | This antibody detects endogenous levels of DCTN3 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 20kD |
| Observed band (KD) | |
| Background | This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013], |
| Function | function:Together with dynein may be involved in spindle assembly and cytokinesis.,similarity:Belongs to the dynactin subunit 3 family.,subcellular location:Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.,subunit:Subunit of dynactin, a multiprotein complex associated with dynein.,tissue specificity:Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain., |
| Subcellular location | Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Cleavage furrow . Midbody . Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells. |
| Expression | Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain. |
Additional Images
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Western blot analysis of lysates from HuvEc cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16989-50
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