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Antibody Product Overview
| ELK.No | ES16992 |
| Product name | DCMC rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 23417 |
| Human Swiss-Prot | O95822 |
| Source | Rabbit |
| Isotype | IgG |
| Target | DCMC |
| Fields | >>beta-Alanine metabolism;>>Propanoate metabolism;>>Metabolic pathways;>>Peroxisome;>>AMPK signaling pathway;>>Alcoholic liver disease |
| Gene name | MLYCD |
| Protein name | DCMC |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 56690 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q99J39 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 85239 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q920F5 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human DCMC AA range: 243-293 |
| Specificity | This antibody detects endogenous levels of DCMC at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 54kD |
| Observed band (KD) | |
| Background | The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:Malonyl-CoA = acetyl-CoA + CO(2).,disease:Defects in MLYCD are the cause of malonyl-CoA decarboxylase deficiency (MLYCD deficiency) [MIM:248360]. MLYCD deficiency is an autosomal recessive disease characterized by abdominal pain, chronic constipation, episodic vomiting, metabolic acidosis and malonic aciduria.,function:Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids.,pathway:Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from malo |
| Subcellular location | Cytoplasm . Mitochondrion matrix . Peroxisome . Peroxisome matrix . Enzymatically active in all three subcellular compartments. . |
| Expression | Expressed in fibroblasts and hepatoblastoma cells (at protein level). Expressed strongly in heart, liver, skeletal muscle, kidney and pancreas. Expressed in myotubes. Expressed weakly in brain, placenta, spleen, thymus, testis, ovary and small intestine. |
Additional Images
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Western blot analysis of lysates from HEK293 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16992-50
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