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Antibody Product Overview
| ELK.No | ES17005 |
| Product name | DBC1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 1620 |
| Human Swiss-Prot | O60477 |
| Source | Rabbit |
| Isotype | IgG |
| Target | DBC1 |
| Fields | |
| Gene name | DBC1 DBCCR1 FAM5A IB3089A |
| Protein name | DBC1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 56710 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q920P3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 140610 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q925T8 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human DBC1 AA range: 100-150 |
| Specificity | This antibody detects endogenous levels of DBC1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 84kD |
| Observed band (KD) | |
| Background | This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers. [provided by RefSeq, Jul 2008], |
| Function | function:Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.,miscellaneous:DBC1 is silenced by methylation in 50% of bladder cancer cell lines.,similarity:Belongs to the FAM5 family.,similarity:Contains 1 MACPF domain.,tissue specificity:Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine., |
| Subcellular location | Cytoplasm . |
| Expression | Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine. |
Additional Images
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Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES17005-100
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