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Antibody Product Overview
| ELK.No | ES1712 |
| Product name | AR-β1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | ADRB1; ADRB1R; B1AR; Beta-1 adrenergic receptor; Beta-1 adrenoreceptor; Beta-1 adrenoceptor |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 153 |
| Human Swiss-Prot | P08588 |
| Source | Rabbit |
| Isotype | IgG |
| Target | AR-β1 |
| Fields | >>Calcium signaling pathway;>>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Adrenergic signaling in cardiomyocytes;>>Gap junction;>>Regulation of lipolysis in adipocytes;>>Renin secretion;>>Salivary secretion;>>Chemical carcinogenesis - receptor activation;>>Dilated cardiomyopathy |
| Gene name | ADRB1 |
| Protein name | Beta-1 adrenergic receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 11554 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P34971 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 24925 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P18090 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ADRB1. AA range:281-330 |
| Specificity | AR-β1 Polyclonal Antibody detects endogenous levels of AR-β1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 51kD |
| Background | The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008], |
| Function | domain:The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.,function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.,PTM:Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.,subunit:Interacts with GOPC, MAGI3 and DLG4., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Early endosome. Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression. . |
| Expression | Placenta, |
Additional Images
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Western Blot analysis of various cells using AR-β1 Polyclonal Antibody
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Western blot analysis of lysates from HT-29 cells, using ADRB1 Antibody. The lane on the right is blocked with the synthesized peptide.
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Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES1712-50
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