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Antibody Product Overview
| ELK.No | ES17216 |
| Product name | CRNL1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 51340 |
| Human Swiss-Prot | Q9BZJ0 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CRNL1 |
| Fields | >>Spliceosome |
| Gene name | CRNKL1 CRN CGI-201 MSTP021 |
| Protein name | CRNL1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 66877 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P63154 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 100910202 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P63155 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human CRNL1 AA range: 710-760 |
| Specificity | This antibody detects endogenous levels of CRNL1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 93kD |
| Observed band (KD) | |
| Background | The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. A protein encoded by this human locus has been found to localize to pre-mRNA splicing complexes in the nucleus and is necessary for pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2013], |
| Function | function:Involved in pre-mRNA splicing process.,similarity:Belongs to the crooked-neck family.,similarity:Contains 17 HAT repeats.,subcellular location:Colocalizes with core spliceosomal snRNP proteins. Also diffusely expressed in cytoplasm.,subunit:Identified in the spliceosome C complex, at least composed of AQR, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRNP200, SNRNP40, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, XAB2 and ZCCHC8. Present in a spliceosom |
| Subcellular location | Nucleus . Nucleus speckle . Colocalizes with core spliceosomal snRNP proteins (PubMed:12084575). . |
| Expression | Widely expressed (PubMed:11342225). Highly expressed in testis (PubMed:12084575). Not detected in brain and lung (PubMed:12084575). |
Additional Images
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Western blot analysis of lysates from A549 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES17216-50
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