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Antibody Product Overview
| ELK.No | ES17336 |
| Product name | COG7 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | Conserved oligomeric Golgi complex subunit 7 (COG complex subunit 7) (Component of oligomeric Golgi complex 7) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 91949 |
| Human Swiss-Prot | P83436 |
| Source | Rabbit |
| Isotype | IgG |
| Target | COG7 |
| Fields | |
| Gene name | COG7 UNQ3082/PRO10013 |
| Protein name | COG7 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 233824 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q3UM29 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 293456 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q3T1G7 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human COG7 AA range: 245-295 |
| Specificity | This antibody detects endogenous levels of COG7 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.332% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 85kD |
| Background | The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.[provided by RefSeq, May 2010], |
| Function | disease:Defects in COG7 are the cause of congenital disorder of glycosylation type 2E (CDG2E) [MIM:608779]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.,function:Required for normal Golgi function.,similarity:Belongs to the COG7 family.,subunit:Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localiz |
| Subcellular location | Golgi apparatus membrane ; Peripheral membrane protein . |
| Expression | Brain,Mammary gland,Synovial membrane, |
Additional Images
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Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES17336-100
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