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Antibody Product Overview
| ELK.No | ES17893 |
| Product name | CACB1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 782 |
| Human Swiss-Prot | Q02641 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CACB1 |
| Fields | >>MAPK signaling pathway;>>Cardiac muscle contraction;>>Adrenergic signaling in cardiomyocytes;>>Oxytocin signaling pathway;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy |
| Gene name | CACNB1 CACNLB1 |
| Protein name | CACB1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 12295 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8R3Z5 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 50688 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P54283 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human CACB1 AA range: 79-129 |
| Specificity | This antibody detects endogenous levels of CACB1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 66kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008], |
| Function | function:The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.,similarity:Belongs to the calcium channel beta subunit family.,similarity:Contains 1 SH3 domain.,subunit:The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with JSRP1.,tissue specificity:Expressed in brain, heart and spleen (isoform 1 and 3) and in skeletal muscle (isoform 2)., |
| Subcellular location | Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein . |
| Expression | Detected in heart ventricle (at protein level) (PubMed:15615847). Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle. |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES17893-100
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