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Antibody Product Overview
| ELK.No | ES17936 |
| Product name | C1GLT rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 56913 |
| Human Swiss-Prot | Q9NS00 |
| Source | Rabbit |
| Isotype | IgG |
| Target | C1GLT |
| Fields | >>Mucin type O-glycan biosynthesis;>>Other types of O-glycan biosynthesis;>>Metabolic pathways |
| Gene name | C1GALT1 |
| Protein name | C1GLT |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 94192 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9JJ06 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 65044 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9JJ05 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human C1GLT AA range: 102-152 |
| Specificity | This antibody detects endogenous levels of C1GLT at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 40kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.[provided by RefSeq, Sep 2010], |
| Function | catalytic activity:UDP-galactose + glycoprotein N-acetyl-D-galactosamine = UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine.,cofactor:Magnesium.,disease:Defects in C1GALT1 may be a cause of susceptibility to IgA nephropathy (IgAN). IgAN is the most common primary glomerulonephritis, which is partly due to aberrant or incomplete galactosylation of IgA1 molecules.,function:Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.,online information:Core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily., |
| Subcellular location | Membrane ; Single-pass type II membrane protein . |
| Expression | Widely expressed. Highly expressed in kidney, heart, placenta and liver. |
Additional Images
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Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES17936-100
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