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Antibody Product Overview
| ELK.No | ES1811 |
| Product name | C9 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | C9; Complement component C9 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 735 |
| Human Swiss-Prot | P02748 |
| Source | Rabbit |
| Isotype | IgG |
| Target | C9 |
| Fields | >>Complement and coagulation cascades;>>Prion disease;>>Amoebiasis;>>Coronavirus disease - COVID-19;>>Systemic lupus erythematosus |
| Gene name | C9 |
| Protein name | Complement component C9 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P06683 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human C9. AA range:181-230 |
| Specificity | C9 Polyclonal Antibody detects endogenous levels of C9 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 70kD |
| Background | This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009], |
| Function | disease:Defects in C9 are a cause of component C9 deficiency (C9D) [MIM:120940]. Patients with C9D suffer from recurrent bacterial infections, predominantly from Neisseria meningitidis.,function:C9 is the final component of the complement system to be added in the assembly of the membrane attack complex. It is able to enter lipid bilayers, forming transmembrane channels.,online information:C9 mutation db,PTM:Thrombin cleaves factor C9 to produce C9a and C9b.,similarity:Belongs to the complement C6/C7/C8/C9 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 MACPF domain.,similarity:Contains 1 TSP type-1 domain., |
| Subcellular location | Secreted . Target cell membrane ; Multi-pass membrane protein . Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore. . |
| Expression | Plasma (at protein level). |
Additional Images
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Western Blot analysis of various cells using C9 Polyclonal Antibody
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Western Blot analysis of COLO205 cells using C9 Polyclonal Antibody
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Western blot analysis of lysates from COLO cells, using C9 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES1811-100
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