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Antibody Product Overview
| ELK.No | ES18188 |
| Product name | ATS15 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAM-TS 15) (ADAM-TS15) (ADAMTS-15) (EC 3.4.24.-) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 170689 |
| Human Swiss-Prot | Q8TE58 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ATS15 |
| Fields | |
| Gene name | ADAMTS15 |
| Protein name | ATS15 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 235130 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P59384 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human ATS15 AA range: 165-215 |
| Specificity | This antibody detects endogenous levels of ATS15 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.207% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 105kD |
| Background | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016], |
| Function | cofactor:Binds 1 zinc ion per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 3 TSP type-1 domains.,tissue specificity:Expressed in fetal liver and kidney, but not in any of the adult tissues examined., |
| Subcellular location | Secreted, extracellular space, extracellular matrix . Cell surface . |
| Expression | Expressed in fetal liver and kidney, but not in any of the adult tissues examined. |
Additional Images
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Western blot analysis of lysates from Jarkat cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES18188-50
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